Evaluation of tylosin tartrate in drinking water for treatment of porcine proliferative enteropathy (ileitis)

Materials and methods: The study consisted of three treatments (Nonchallenged– unmedicated, Challenged–unmedicated, and Challenged–medicated), with six pens of six pigs per treatment (N = 108 pigs). Pigs 28 days old were challenged orally on Days 0 and 1 with L intracellularis. Drinking water medicated with tylosin tartrate (Tylan Soluble Powder; Elanco Animal Health, Indianapolis, Indiana) was provided to medicated pens Days 10 to 17. Pigs were weighed daily and assigned clinical scores, and feed consumption was measured. At necropsy (Days 17 and 18), gross lesions consistent with porcine proliferative enteropathy (PPE) were recorded, and tissues were collected for histopathologic examination and testing by polymerase chain reaction (PCR).